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3 Despite regulatory parameters for e-liquids, such as maximum nicotine concentration of 20 mg/ml having been already proposed worldwide, e-liquid solutions with nicotine concentrations of up to 60 mg/ml may be increasingly more easily purchased online, facilitating the occurrence of fatal cases following both accidental and intentional e-liquid intake gradually becoming a relevant health problem worldwide

The combination of abrasive tobacco particles, nicotine-induced vasoconstriction, and direct carcinogen exposure damages soft tissue progressively

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