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It is difficult to establish strong associations between arsenic exposure and disease, as the prevalence and spectrum of diseases linked to chronic arsenic exposure differ not only between countries, but even within countries

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This topic isnt fully understood as metabolism is a complex process, and many pathways within our metabolism can be affected

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HDAC8 has been shown to attenuate acetylation of Histone H3 and H4 in the IFN - promoter, resulting in suppression of IFN - transcription, which leads to the inhibition of innate IFN - production [140]