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Fifty-three long-term male smokers and 53 well-matched male healthy non-smokers participated in the study, and the smokers were respectively categorized into light and heavy tobacco consumption subgroups by pack-years and into moderate and severe nicotine dependence subgroups using the Fagerstrm Test for Nicotine Dependence (FTND)

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As a corollary, it makes it harder for them to start smoking at a time when their brains may be particularly vulnerable to the effects of nicotine