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Together, the presence of these signatures in nonmalignant, chronically exposed cells supports the idea that long-term cigarette exposure acts both as a genotoxic insult and as a selective pressure favoring cells capable of enduring genomic stress 20,26,27

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Aside from death, as many as 1 million UK residents suffer from a debilitating chronic disease, and 500,000 hospital admissions are caused as a direct effect of smoking

While the presence of NNAL at all indicated that participants still smoked cigarettes, the lower levels suggest that the e-cigarettes assisted in cutting back on their normal smoking levels, with the 5%-nicotine group experiencing greater reductions in exposure