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[49] In the United Kingdom, guidance from the National Institute for Health and Care Excellence notes that, as of February 2025, no nicotine-containing e-cigarettes were licensed as medicines for smoking cessation by the Medicines and Healthcare products Regulatory Agency, and products not licensed as medicines cannot be marketed by manufacturers for stopping smoking

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Cilia loss, mucosal thinning, and hyperplasia of the tracheal mucosa are phenotypic responses consistent with the major alteration of the proteome identified in this study