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James Bonsack (a son of a Roanoke textile titan) at an early age became familiar with how machines made textiles (machine-made cloth), and at the age of 21 in 1881, he patented the Bonsack Cigarette Machine

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The chemicals in cigarettes, the act of inhaling, and the heat generated during smoking all work against your bodys natural ability to heal

Mechanism 5 Antibody Disruption Immunoglobulin Production Altered Vaccine Responses Reduced Smoking alters the pattern of immunoglobulin (antibody) production increasing IgE (associated with allergic responses) while impairing IgG and IgA responses (associated with infection defence)