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Taken together, DNA methylation at any given CpG is the result of multiple processes that are orchestrated as a developmental cascade involving, first, global demethylation after fertilization, then, cell/tissue-specific re-methylation during very early embryogenesis and, finally, maintenance of DNA methylation throughout the remainder of life

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Public health interventions should continue to emphasize the overall health improvements associated with smoking cessation. Even outside of cigarettes, breathing in substances such as marijuana, air pollution and cooking smoke has been associated with an increase in cardiovascular and lung disease, Freeman added