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Baseline adjustment was performed by subtraction of the pre-existing nicotine concentration from each nicotine concentration obtained after test product administration in that period/day for each subject using the following equation: where C t is the adjusted concentration at time t, C t unadjusted is the observed concentration at time t, C 0 is the pre-product use concentration (5 min), Kel = ln(2)/t, t is 2 h (approximate nicotine half-life), t is the actual sampling time since product administration, and t1 is the actual sampling time since the time of the pre-product use sample

The word "CLIPPER" should be clearly printed or embossed on the lighter body, and on genuine models you'll also see "reusable" branding

for smoker vs

PMID 10756510

Leaf quality can also be negatively affected if weeds physically damage tobacco before or during harvest