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It is a complex chemical cocktail of two distinct phases: a particulate phase (solid and liquid particles suspended in air) and a gas phase (volatile organic compounds, carbon monoxide, nitrogen oxides, and dozens of other chemical gases)

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According to Teshamae Monteith, a doctor and one of the authors from the University of Miami, Miller School of Medicine, "One possible mechanism of increased stroke risk may be oxidative stress, which has been theorized to have a role in migraine and may lead to increased susceptibility to vascular events among active smokers." While migraines themselves did not signal a greater risk of stroke, smokers who also had migraines were three times as likely to have a stroke, said the researchers in the Northern Manhattan Study