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Finally, methylation levels are often correlated across multiple neighboring CpGs and this co-methylation is stronger for CpGs inside CGIs than outside CGIs ( ENZYMES OF DNA METHYLATION Methylation of DNA is catalyzed by three families of DNA methyltransferases: DNMT1, DNMT2, and DNMT3 ( DNMT1 is responsible for life-long maintenance of DNA methylation during cell division it copies DNA methylation marks from the original to the nascent strand during DNA replication (Tang et al., 2009)

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