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Given that the issue [of safety] has not been definitively settled, and given that e-cigarette aerosol contains other chemicals in addition to nicotine, objective data on pregnancy outcomes in women who switch from smoking to e-cigarette use are urgently needed, Peter Hajek, PhD , director of the health and lifestyle research unit at Queen Mary University in London, and colleagues wrote

Managing Tobacco Use During Detoxification What strategies can help manage tobacco use during detox

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These sedating effects tend to be more likely to occur when higher doses of cannabis are taken, but some people experience these depressant effects even in small doses