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Proposed 428.202(c)(4) further provides that for a Part D rebatable drug first approved or licensed after October 1, 2021 (that is, a subsequently approved drug), for which there are no quarters during the first calendar year beginning after the drug's first marketed date for which AMP has been reported under section 1927(b)(3), the payment amount benchmark period would be the first calendar year in which such drug has at least 1 quarter of AMP reported

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Second, the outcome exhibited a high proportion of zero values and substantial variability, requiring alternative modeling strategies

Oral cancer is two to three times more common in men than women across most ethnic groups

Dispose of the gum properly once the nicotine is fully released