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For cohort studies, we utilized the Newcastle-Ottawa Quality Assessment Scale for quantitative analysis, the Newcastle-Ottawa Scale was developed to assess the quality of nonrandomized studies with its design, content and ease of use directed to the task of incorporating the quality assessments in the interpretation of meta-analytic results (20)

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The researchers first observed, unsurprisingly, that smokers had a much higher risk of heart disease (almost 2 times) than non-smokers (see Figure 1)