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LS, AK, and MdM declare that they have no competing interests

Epidemiological evidence highlights a latitude-dependent variation in MS incidence, suggesting that reduced UV radiation exposure and subsequent lower endogenous vitamin D synthesis may predispose individuals to MS [56]

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We have carefully chosen a publicly available oral microbiome dataset of OSCC patients similar to the sampling site, sample collection procedure, and sequencing platform used in our study (Zhao et al., 2017)