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The H 2 O was added to the NMR sample to enable better resolution of the OH proton peaks of 1a-d from an overlapping resonance

The plain packaging legislation also empowers the Ministry of Health to periodically update graphic health warnings and labels to ensure their effectiveness and relevance, and more strongly enforce their use. WHO recommends that plain packaging be used as part of a comprehensive approach to tobacco control, which includes complete bans on tobacco advertising, promotion, and sponsorship, other tobacco packaging and labeling measures, and both supply and demand reduction measures such as tobacco taxes and ongoing enforcement of regulations.

Meernik C, Baker HM, Kowitt SD, Ranney LM, Goldstein AO

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Chaumont M, van de Borne P, Bernard A, Van Muylem A, Deprez G, Ullmo J, et al