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The COI levels were categorized as No-COI, Low, Moderate, or High. When a COI was declared, the committee determined the appropriateness of involvement based on these categories (Supplementary Table 1)

At first these pipes were used to smoke tobacco but very quickly cannabis flowers and hashish were mixed in

Those who smoke may be more sensitive to reduced exposure marketing claims and may have an increased inclination toward IQOS use

A recent major analysis in Addictive Behaviors found that e-cigarettes are more effective for quitting than traditional nicotine replacement therapies (NRT) like patches or gum (2)

This is why nicotine is so addictive as it quickly stimulates your brain to feel good, but that feeling fades fast, leading you to crave more