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[21] USDA, National Agricultural Statistics Service, Crop Production 2012 Summary , January 2013, p

While the complex nature of this mixture makes it difficult to tease out the chemicals responsible for the toxicity of tobacco smoke and air pollution, the toxicity of some of the largest classes of chemicals have been clearly demonstrated, especially particulate matter 53

They also had the highest concentration of tobacco specific N-nitrosamines, at the time this study was conducted

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