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As our in vivo scRNA-seq data did not wholly capture the heterogeneity reflective of this progression, we studied the process by culturing basal tracheal epithelial cells at airliquid interface (ALI) and harvesting replicate cultures at 20 timepoints across mucociliary differentiation for scRNA-seq analysis (Fig

While the US Food and Drug Administration (FDA) has authorised PMI to market multiple heated tobacco products, it also declared that this "does not mean these products are safe nor FDA approved"