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The hyperpolarization of POU2F3 and FOXI1 KO cultures could result from disruption of ionocyte-enriched CFTR, which would be consistent with CFTR mutant/KO data from mice and human cell cultures 61,62 , as well as nasal potential difference measurements in individuals with cystic fibrosis 63

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This pro-inflammatory response of epithelial cells to CSE is achieved by altering a variety of signaling pathways involved in cellular activation, primarily protein kinase C (PKC), mitogen-actived protein kinase (MAPK), NFB and activatory protein-1 (AP-1) pathways [102,134,135,136]

Hookah (shisha) causes the same diseases that regular cigarettes do, and an hour-long hookah session is equivalent to smoking 10 cigarettes, according to the CDC