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The focus on smokeless tobacco, a broad and ambiguous grouping of tobacco products, in existing attempts to quantify health risks has also obscured the distinct risk patterns associated with chewed and non-chewed forms of smokeless tobacco

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According to Fennell, A.s 2020 study, Phasic Dopamine Release Magnitude Tracks Individual Differences in Sensitization of Locomotor Response following a History of Nicotine Exposure., repeated nicotine exposure significantly decreases dopamine release in the nucleus accumbens (NAc) core of the brain through changes in 62 receptor modulation

Yilmaz M, Kantarjian HM, Jabbour EJ, O'Brien SM, Borthakur G, Verstovsek S, Garcia-Manero G, Ravandi F, Burger JA , Pierce SA, Quints-Cardama A, Cortes JE

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