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The individuals balance between the metabolic detoxification and activation of carcinogens vary and contributes to the differential pathological response in smokers with some developing cancer in just a couple of months while others taking years of chronic exposure to develop any pathology [7, 24, 25]
For men the prevalence decreased from 36.5% in 2000 to 22% in 2015, with a further decrease to 16% projected by 2025
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