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Effect of Concomitant Use of Benzodiazepines and Opioids: The concomitant use of benzodiazepines and opioids increases the risk of respiratory depression because of actions at different receptor sites in the CNS that control respiration

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They also tend to be the most cost effective of all the e-cigarette types

Weighing the Evidence: Evaluating the Social Benefits and Costs of the Australian Tobacco Industry (Cancer Council Western Australia, 2009)

Tuyns AJ, Pquignot G, & Jensen OM (1977) Le cancer de l'oesophage en Ille-et-Vilaine en fonction des niveaux de consommation d'alcool et de tabac: Des risques qui se multiplient