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The manual outlines criteria to identify problematic use, which include: Tolerance Substance-specific withdrawal syndrome The substance is often taken in larger amounts or over a longer period than expected Persistent desire or unsuccessful efforts to cut down or control the use A great deal of time is spent in activities necessary to obtain, use, or recover from the effects of the substance Important social, occupational, or recreational activities are given up or reduced because of the substance Use continued despite knowledge of a persistent or recurrent physical or psychological problem likely to have been caused or exacerbated by the substance In addition to these criteria, the DSM-5-TR formally recognizes Caffeine Withdrawal as an official clinical diagnosis

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12]**PEER REVIEWED** EXTRACTION OF VARIOUS PRINCIPLES FROM ANIMAL AND PLANT SUBSTANCES