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The ROS produced are converted to peroxynitrite, which has a very strong cytotoxic effect when combined with NO, resulting in direct damage to vascular wall cells and a decrease in the biological activity of NO in vascular endothelial cells and vascular smooth muscle cells [68]

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According to Jacob Shelley of Canadas Western University, the deal could represent the largest settlement agreement of its kind ever reached outside the US, with up to CAD 100,000 awarded per individual victim, relative to the type and severity of the illness and the duration of tobacco use