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A 2018 Conference Board of Canada report estimated smoking-related illnesses cost the health-care system $6.5 billion a year

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Some causes include: Burning of the tissue from extremely hot temperature or acidity Stress Sharp teeth, braces, ill-fitting dentures Cigarette smoking Allergies Underlying health condition Symptoms: Small shallow round ulcer that is gray, white, or yellow and can be surrounded by redness Painful sore that can appear anywhere in the mouth such as the tongue, gums, cheek, or palate May have accompanying symptoms of sluggishness or lethargy, fever, diarrhea, joint/body pain, a rash, swollen lymph nodes Treatment Canker sores typically clear on their own within 1-2 weeks

*Mol Med Rep*