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30 A possible biomolecular mechanism of HSV-mediated neuronal dysfunction involves abnormal expression of p53 upregulated modulator of apoptosis (PUMA) and the innate immune signaling molecule, SARM1

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Moreover, with an average life loss of at least ten years, tobacco smoking causes more than half of all long-term smokers to pass away (Prochaska & Benowitz, 2019)