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Potential harm due to flavor chemicals is further supported by an in vitro study in which maltol increased secretion of IL-8 from BEAS-2B cells and decreased barrier function in human bronchial epithelial cells 30 and by animal studies in which maltol produced long-term adverse health effects in rats and dogs 31 and elicited liver and kidney damage in mice 32
Among high school students who vape, mint and menthol was the second-most popular flavor behind fruit, according to preliminary data from the Centers for Disease Control and Prevention's 2019 National Youth Tobacco Survey
Regulatory frameworks are stringent, with clear labeling requirements, excise taxes, and marketing restrictions, which influence pricing strategies and product positioning
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