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In other words, smoking increases the risk and severity of respiratory infections because of the damage it causes to the airways, the resultant weakening in respiratory immune functions as a consequence of the same

In their analyses, researchers looked at the rates of high blood pressure, heart attack, stroke, coronary artery disease, diabetes and depression/anxiety among those who reported using e-cigarettes (either some days or daily) and nonusers

Verzuh, Valerie K., Suzan Shown Harjo, and David Bradley

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The combination is particularly dangerous, as clots can travel to the brain, or blood vessels in the brain can rupture