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Clozapine had been pulled from the market in the 1970s after fatal cases of severe neutropenia in Finland, but the pivotal Kane and colleagues trial in 1988 showed clozapine to be highly effective for treatment-resistant schizophrenia

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Smokers of Camels were even encouraged to smoke a cigarette between every course of a Thanksgiving mealas an aid to digestion. Except for a brief period around the Great Depression, per capita cigarette consumption increased steadily until 1953, by which time 47% of American adults were smoking cigarettes and half of all physicians