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We found that, due to small numbers of studies, inconsistency in the data, small effect sizes or a combination of these reasons, seven outcomes for which some previous research had found an association with smoking did notunder our meta-analytic framework and conservative approach to interpreting the datahave evidence of an association

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Upon entering the blood, nicotine immediately stimulates the adrenal glands to release the hormone epinephrine (adrenaline)

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