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Several studies have shown that the mtDNA is prone to oxidant/toxicant-induced damage through the formation of strand breaks, thymidine dimer formation, bulky adducts and mtDNA copy number depletion or deletions ( reviewed in 45 )

This is not simply a matter of carrying over continuity from one movie into its sequel, but the specific circumstances of John quitting were central to his story and growth in Constantine

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Dimensions: 2000 x 3000 px | 16.9 x 25.4 cm | 6.7 x 10 inches | 300dpi Date taken: 14 September 2012 Photographer: WENN More information: This image could have imperfections as its either historical or reportage.