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Smokers who increased their varenicline dose after a failed first attempt were seven times more likely to quit, and those who switched from CNRT to varenicline had nearly double the success rate compared to those who continued their original treatment or switched from varenicline to CNRT
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Indeed, when nicotine is administered concurrently with a CYP2A6 inhibitor of unknown strength, the substrate metabolism will be reduced, resulting in increasing serum concentrations and heightened risk, incidence, and/or severity of ADRs
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