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The 180 smokers were systematically selected based on the smoking severity: mild smokers (n=60) 2 and 10 cigarettes/day, based on the available literature 35,36
While early generation E-cigarettes were associated with lower dependence than cigarettes, this may not apply to modern high nicotine pouches, which deliver nicotine efficiently (10, 15)
(Not to mention the fact that there is also significantly less progesterone than the alternatives)
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