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CRC: has received honoraria for lecturing, scientific advice, participation in clinical studies or writing for publications from J&J, Aflofarm, GSK, Menarini, Mundipharma, Novartis, Chiesi, Pfizer, and Teva

Solar radiation, especially UV, is known to induce the activation of the MAPK pathways 5,29 , which in turn can upregulate the MMP expression 30,31 and alter the TGF-/Smads pathway 29

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