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Specific actions involve blocking signaling pathways such as transforming growth factor- (TGF-) and cyclic adenosine monophosphate/protein kinase A (cAMP/PKA), reducing ECM synthesis by inhibiting synthases, and modulating inflammatory mediator secretion to alleviate inflammatory responses (146, 147)

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The mNSC were cultured in Dulbeccos Eagles Medium (DMEM) (Lonza Walkersville, MD) supplemented with 10% fetal bovine serum, 5% horse serum, and 1% each penicillin-streptomycin (GIBCO, Invitrogen, Carlsbad, CA) and sodium pyruvate