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37 Acknowledgments The authors wish to thank Dr Alison OMara-Eves and Dr Dylan Kneale from the EPPI-Centre, at the Institute of Education (University College London), for acting as independent external assessors to conduct critical appraisal of each of the studies included within the two source reviews

and (3) the fact that we verified that the EI mass spectra of the methyl pyrrolidine nicotine analogs as obtained from KemPharma (Gainesville, FL) are distinctly different from those of the Fig