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HDL levels over 116 mg/dL for men or 135 mg/dL for women cause an increase in the risk of heart disease.[ref] HDL cholesterol also plays a role in the immune system, with higher levels of HDL associated with better outcomes from parasites and bacterial infections.[ref] Genetics and HDL: HDL cholesterol levels are considered to be about half due to genes (with the rest due to diet, infection, etc.).[ref][ref] CETP gene: The CETP gene codes for the cholesteryl ester transfer protein, which moves triglycerides or cholesterol between VLDL or LDL and HDL particles

Another study found calls to Quitline, an Australian government service to help people quit smoking, rose by 78 percent after the plain packaging laws came into effect