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Patterns of global tobacco use in young people and implications for future chronic disease burden in adults

In circumstances in which negative or zero manufacturer's ASP data is reported for all NDCs for a biosimilar for a given quarter and either no other biosimilars have been approved for the same reference product or no other biosimilars with the same reference product report positive manufacturer's ASP data for the given quarter, we propose that we would set the payment limit for the given quarter equal to the sum of the following until at least one NDC for the biosimilar has positive manufacturer's ASP data for a quarter: The volume-weighted average of the most recent available positive manufacturer's ASP data from a previous quarter, and 6 percent (or 8 percent for qualifying biosimilar biologicals, as appropriate) of the amount determined under section 1847A(b)(4) of the Act for the reference biological product (as defined in 414.902) for the given quarter

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Other ways smoking can harm your body There is no such thing as a safe cigarette or a safe level of smoking, as even younger people who smoke can experience serious health problems