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However, the studies included mostly viewed smoking as a dichotomous factor or used pack-years as the indicator of ones smoking history

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Chemotherapy and medications like tamoxifen or raloxifene also contribute to the risk

California Department of Public Health, California Tobacco Control Program, California Student Tobacco Survey (CSTS) 2011-2012

However, the Joker of the movies typically reflects Batmans tone , with grittier adaptations of the hero translating to equally gritty adaptations of the villain