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It has been shown that HDAC6 inhibition confers protective effects against LPS-induced inflammation, as is demonstrated by the reduced production of the pro-inflammatory cytokines TNF - , IL - 1 , and IL - 6 and decreased leukocyte infiltration [137, 138]

This analysis is based on primary and secondary research conducted through Q4 2025, with data verified as of March 2026

The name Mafate comes from the Malagasy word mahafaty , which means lethal or the one who kills, an allusion to the difficulty in accessing this cirque