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Chronic obstructive pulmonary disease (COPD) is consistently among the top 10 most common chronic health conditions and among the top 10 conditions that limit daily activities

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13,40,82 This suggests that smoking-related damage is not only associative, but also mechanistically testable The next step is to build standardized models that study cigarette smoke and EC aerosol separately, with clear control of exposure chemistry, nicotine level, device setting, and dose

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