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Interestingly, the elevation of aldose reductase expression results in the activation of the polyol pathway, leading to two main consequences: the blockade of nitric oxide production and the production of endogenous fructose

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[11] The CDC also notes that, "However, because low-income groups are more responsive to price increases, increasing the real price of cigarettes can reduce cigarette consumption among low income smokers by a greater percentage than among higher income smokers, and thereby diminish socioeconomic smoking disparities

There were also cases when users smoked cigarettes and switched to e-cigarettes