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Individual Member States may also require manufacturers or importers to carry out studies as may be prescribed by the competent authorities in order to assess the effects of ingredients on health, taking into account, inter alia, their addictiveness and toxicity

An individual was considered to be a smoker if he/she consumed a minimum of one cigarette per day for a period of at least six months

[PubMed: 23121148] Kreimer AR, Johansson M, Waterboer T, et al.: Evaluation of human papillomavirus antibodies and risk of subsequent head and neck cancer