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Animal study design Adult female sheep (ewes) were used in all experiments because male sheep are naturally more aggressive and thus not amenable for long-term experimentation without the use of general anesthesia

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In Canada, where two provinces banned tobacco displays, there was inconclusive evidence that it led to a decline in underage sales since youth smoking fell further in provinces without a display ban

At present, it is impossible to reach a consensus on the safety of e-cigarettes except perhaps to say that they may be safer than conventional cigarettes but are also likely to pose risks to health that are not present when neither product is used, wrote physicians Chitra Dinakar and George OConner in The New England Journal of Medicine in 2016

10, 2025, the agency said