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Neuronal nAChRs are central regulators of neurophysiology and signaling in addiction pathways (Dani & Balfour, 2011

Consumption method: Smoking, vaping, or baking cannabis products quickly decarboxylates THCa, producing psychoactive effects, whereas consuming raw cannabis (e.g., in smoothies or juices) preserves THCa in its original form

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In contrast, other attempts have been made to develop non-cigarette-specific dependence measures for smokeless tobacco, e-cigarettes, and waterpipes 16,17,18,19