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These effects were independent of nicotine concentration, as the presence of pure nicotine extract resulted in the inhibition of platelet functions, suggesting that maybe other constituents of electronic cigarettes can antagonise normal platelet function

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42 In addition, CCL2-CCR2 signaling activates CCL3-CCR1 signaling in MAMs, which support MAM accumulation at the metastatic site, 59 which enhances signaling pathway-mediated metastatic cell growth via the FMS-like tyrosine kinase 1-focal adhesion kinase (FAK1)-CSF1 and CSF1-C-ets-2-microRNAs pathways in macrophages