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Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1

Common triggers include excess caffeine and energy drinks (see young adults and heart risk), alcohol especially binge drinking, which can provoke holiday heart (see alcohol and your heart) poor sleep and untreated sleep apnoea (see sleep and your heart), dehydration, intense stress, certain medicines and stimulants, and an overactive thyroid (see the thyroidheart connection)

Some people over-treat their nasal congestion with nasal sprays and become dependent upon it in order to breathe more easily (a disorder called rhinitis medicamentosum)