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Vitamin E oil has been the leading culprit in the lung damage, though other chemicals and additives can't be ruled out, according to the CDC

In 2015, the Nobel Prize in Physiology or Medicine was awarded in part for the discovery of artemisinin, a plant-derived compound thats proven to be a lifesaver in treating malaria

However, as the person becomes used to the effects of tobacco, these reasons for smoking tend to diminish as the alleviation of withdrawal symptoms such as low mood, irritability, poor concentration, restlessness and anxiety gain prominence (Benowitz Reference Benowitz, Hukkanen, Jacob, Henningfield, London and Pogun2010

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