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Moreover, the TGF-1/Smad2.3 signalling pathway is strongly implicated in endothelial to mesenchymal transition (EndMT) which plays a key role in the pathogenesis of COPD [129,130,131]

All statistical analyses were performed using SAS version 9.4 (SAS Institute Inc., Cary, NC, USA) and R version 4.0.3 (R Foundation for Statistical Computing, Vienna, Austria)

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