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Overall, current research suggests: Vaping tends to have fewer harmful chemicals than heated tobacco, Heated tobacco has fewer harmful chemicals than cigarettes, 2Cell Toxicity & Long-Term Impact Early laboratory studies indicate that aerosols from both heated tobacco and vaping can affect lung cells, but to different degrees: Heated tobacco aerosolbecause it comes from real tobaccooften shows higher cytotoxicity than vaping aerosol, while still being lower than cigarette smoke